14-3-3-pan(Acetyl Lys51/49) Polyclonal Antibody, 50ul Protein Post-translational Modification When overexpressed in mammalian cells

When overexpressed in mammalian cells

The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex

which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377

Some individuals

and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system

14-3-3-pan(Acetyl Lys51/49) Polyclonal Antibody, 50ul Protein Post-translational Modification When overexpressed in mammalian cellsThis gene encodes a protein belonging to the 14 3 3 family of proteins members of which mediate signal transduction by binding to phosphoserine containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants which encode the