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INGR2 Polyclonal Antibody, 20ul Inoculating Loops/Needles An important paralog of this

SKU: 71327229207

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INGR2 Polyclonal Antibody, 20ul Inoculating Loops/Needles An important paralog of thisThis gene (IFNGR2) encodes the non ligand binding beta chain of the gamma interferon receptor. Human interferon gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X linked inheritance.

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Description

An important paralog of this gene is NDUFC2-KCTD14

all three genes may be implicated in the 5-q syndrome

It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system

This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation

The human genome contains several non-transcribed pseudogenes related to this gene

INGR2 Polyclonal Antibody, 20ul Inoculating Loops/Needles An important paralog of thisThis gene (IFNGR2) encodes the non ligand binding beta chain of the gamma interferon receptor. Human interferon gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X linked inheritance.

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