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p53R2 Polyclonal Antibody, 100ul Vessels This protein may be involved

SKU: 71732105705

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p53R2 Polyclonal Antibody, 100ul Vessels This protein may be involvedRRM2B encodes the small subunit of a p53 inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in RRM2B have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia 5, and mitochondrial

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Description

This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside

Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed: 25361978)

docosahexaenoic acid

may play a role in the mucosal/epithelial immune response and epidermal differentiation

FOXR1 encodes a member of the forkhead box (FOX) family of transcription factors

p53R2 Polyclonal Antibody, 100ul Vessels This protein may be involvedRRM2B encodes the small subunit of a p53 inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in RRM2B have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia 5, and mitochondrial

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