HSC 70 Polyclonal Antibody, 20ul[BT-AP10168] ROS/Nitric Oxide Detection Mutations in this gene cause

Mutations in this gene cause X-linked agammaglobulinemia type 1| which is an immunodeficiency characterized by the failure to produce mature B lymphocytes| and associated with a failure of Ig heavy chain rearrangement

The encoded protein contains a homeobox DNA-binding domain

and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells

Mutations in this gene are implicated in Bardet-Biedl syndrome

Kruppel-related proteins form 1 family of zinc finger proteins

HSC 70 Polyclonal Antibody, 20ul[BT-AP10168] ROS/Nitric Oxide Detection Mutations in this gene causeThis gene encodes a member of the heat shock protein 70 family, which contains both heat inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin coated vesicles during transport of membrane components