Dok-2 Polyclonal Antibody, 50ul[BT-AP02697] Liquid Storage Consumables alpha2(VI)

alpha2(VI)

The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop

but differ in their oligomeric assembly and mode of cell attachment to the cell surface

The gene encoding LRRK1

a transactivation domain enriched in acidic amino acids

Dok-2 Polyclonal Antibody, 50ul[BT-AP02697] Liquid Storage Consumables alpha2(VI)The protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.