PYK2 Polyclonal Antibody, 50ul[BT-AP07520] Microplate Mixer Multiple alternatively spliced variants| encoding

Multiple alternatively spliced variants| encoding the same protein| have been identified

Some Bartter-like syndromes result from defects in this gene

The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins

and are upregulated in psoriasis

Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome

PYK2 Polyclonal Antibody, 50ul[BT-AP07520] Microplate Mixer Multiple alternatively spliced variants| encodingPTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and