CALRL Polyclonal Antibody, 50ul Cell Function Analysis OGF is a negative regulator

OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes

The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage

and both are required for IL23A signaling

Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities

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CALRL Polyclonal Antibody, 50ul Cell Function Analysis OGF is a negative regulatorReceptor for calcitonin gene related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,Belongs to the G protein coupled receptor 2 family.,subunit: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.,tissue specificity: Predominantly expressed in the lung and heart.,