beta -Arrestin 1(Phospho-Ser412) Rabbit Polyclonal Antibody, 20ul Drying & Desiccation A nuclear localization signal (NLS)

A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon

This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing

and one delta subunit

but the full-length nature of only some of these variants has been described

tissue specificity:Leukemic stem cell

beta -Arrestin 1(Phospho-Ser412) Rabbit Polyclonal Antibody, 20ul Drying & Desiccation A nuclear localization signal (NLS)Members of arrestin beta arrestin protein family are thought to participate in agonist mediated desensitization of G protein coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones neurotransmitters or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta adrenergic receptor kinase (BARK) mediated desensitization of beta adrenergic receptors. Besides the central nervous