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RFOX1 Polyclonal Antibody, 50ul Buffer Solutions Unlike other DOK family proteins

SKU: 75679766099

4.7
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RFOX1 Polyclonal Antibody, 50ul Buffer Solutions Unlike other DOK family proteinsThe Fox 1 family of RNA binding proteins is evolutionarily conserved, and regulates tissue specific alternative splicing in metazoa. Fox 1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C terminus of ataxin 2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin 2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox 1 and ataxin

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Description

Unlike other DOK family proteins

as well as X-linked combined immunodeficiency (XCID)

but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect

The encoded protein shares a high level of similarity to the rat homolog| and contains 3 C2 domains and a diacylglycerol-binding C1 domain

and a minor mediator of the JNK pathway

RFOX1 Polyclonal Antibody, 50ul Buffer Solutions Unlike other DOK family proteinsThe Fox 1 family of RNA binding proteins is evolutionarily conserved, and regulates tissue specific alternative splicing in metazoa. Fox 1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C terminus of ataxin 2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin 2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox 1 and ataxin

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