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Can we assume that those effects are real given that they were FDA approved for other things

This is usually an indication that you have a methylation defect and need to slow down on the amount of B12 you are taking

55 SakamotoK.YonokiY.KubotaY.KuwagataM.SaitoM.NakaharaT.et al (2006)

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Interestingly, in Brassica napus exposed to cadmium, phytochelatins as well as GS-cadmium complexes were found at high concentrations in the phloem whereas phytochelatin concentrations were much lower in the xylem (Mendoza-Czatl et al., 2008)