AP4B1 Rabbit Polyclonal Antibody, 50ul Micro Centrifuge Tubes DNA damage inducible transcript 3

DNA damage inducible transcript 3 functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members

This gene is itself transcriptionally-regulated by p53

a single transmembrane domain (in some isoforms)

Expression of the encoded protein is able to induce apoptosis

The encoded protein is an integral membrane protein and may be localized to the basolateral membrane

AP4B1 Rabbit Polyclonal Antibody, 50ul Micro Centrifuge Tubes DNA damage inducible transcript 3This gene encodes a subunit of a heterotetrameric adapter like complex 4 that is involved in targeting proteins from the trans Golgi network to the endosomal lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.