GIT2 Polyclonal Antibody, 100ul Antibody Humanization Phosphorylates and activates MAP2K4 and

Phosphorylates and activates MAP2K4 and MAP2K6| which in turn activate the JNK and p38 MAP kinases| respectively

This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport

Two transcripts that encode the same protein have been identified for this gene

General transcription factor 3C polypeptide 3 encoded by GTF3C3 is part of the TFIIIC2 complex

It plays a negative regulatory role in the Ras-Raf1-MAPK pathway| and knockout mice have been shown to develop spontaneous tumors| suggesting a role as a tumor suppressor gene

GIT2 Polyclonal Antibody, 100ul Antibody Humanization Phosphorylates and activates MAP2K4 andGIT2 encodes a member of the GIT protein family, ARF GTPase activating protein GIT2, which interact with G protein coupled receptor kinases and possess ADP ribosylation factor (ARF) GTPase activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins.