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WAVE1(Phospho Tyr125) Polyclonal Antibody, 20ul Cell Culture Plates two nonphosphorylatable alkali light chains

SKU: 77369382719

4.6
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WAVE1(Phospho Tyr125) Polyclonal Antibody, 20ul Cell Culture Plates two nonphosphorylatable alkali light chainsThe protein encoded by this gene, a member of the Wiskott Aldrich syndrome protein (WASP) family, plays a critical role downstream of Rac, a Rho family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2 3 complex while enhancing actin polymerization in vitro. Wiskott Aldrich syndrome is a disease of the immune system, likely due to defects in regulation

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Description

two nonphosphorylatable alkali light chains

and repress transcription through two partially redundant C-terminal domains

MIM 610611)

Mutations and alternative splicing in TSG101 occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression

Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis

WAVE1(Phospho Tyr125) Polyclonal Antibody, 20ul Cell Culture Plates two nonphosphorylatable alkali light chainsThe protein encoded by this gene, a member of the Wiskott Aldrich syndrome protein (WASP) family, plays a critical role downstream of Rac, a Rho family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2 3 complex while enhancing actin polymerization in vitro. Wiskott Aldrich syndrome is a disease of the immune system, likely due to defects in regulation

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