FAM111B Polyclonal Antibody, 50ul sgRNA Library Construction CENPB (MIM 117140)

CENPB (MIM 117140)

Expressed at lower levels in kidney

Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE)

promotion of angiogenesis

this protein has 12 or more transmembrane alpha-helix domains that likely arrange to form a single central chamber with multiple substrate binding sites

FAM111B Polyclonal Antibody, 50ul sgRNA Library Construction CENPB (MIM 117140)FAM111B encodes a protein with a trypsin like cysteine serine peptidase domain in the C terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog