53BP1 Polyclonal Antibody, 100ul[BT-AP00040] Dry Bath nephronophthisis

nephronophthisis

May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles

It is highly similar to human annexins I and II sequences

The protein encoded by SLC4A10 was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions

This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity

53BP1 Polyclonal Antibody, 100ul[BT-AP00040] Dry Bath nephronophthisisThe p53 binding proteins 53BP1 and 53BP2 (Bbp) bind to the central DNA binding domain of wild type p53, but do not bind mutant p53. The central DNA binding domain of p53 is required for site specific DNA binding and is frequently mutated in malignant tumors. Binding of 53BP1 to the L3 loop of p53 and of 53BP2 to the L2 loop of p53 confirms that the loop is dependent on p53 conformation. Site specific binding also suggests that 53BP1 and 53BP2 are