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Though tirzepatides use for weight loss in non-diabetic individuals is off-label, research has shown it can result in significant weight loss

The results were clear

They are distinct molecules that work through distinct mechanisms, and treating them as simple substitutes for each other misses critical pharmacological nuances that affect safety and efficacy

Lilly cautioned in its announcement that SYNERGY-NASH was not designed to prove that tirzepatide improves fibrosis. Still, the press release stated that the study results showed the potential for a clinically meaningful treatment effect across all doses. Tirzepatide also induced notable improvements in body weight, liver injury markers and biomarkers of fibrosis, inflammation and liver fat, according to Lilly

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