Rb(Phospho Thr821) Polyclonal Antibody, 50ul Bottles Methylation of the genes promoter

Methylation of the genes promoter has been associated with several cancer types

Belongs to the TFB2 family

This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin| and it appears to play a role in calcium homeostasis in the ER

but the biological validity and the full-length nature of some variants have not been determined

ADORA3 shares its 5' terminal exon with some transcripts from overlapping GeneID: 57413

Rb(Phospho Thr821) Polyclonal Antibody, 50ul Bottles Methylation of the genes promoterThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.