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Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis

It is a secreted protein and may function as a homodimer

Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11)

Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates

p27 Monoclonal Antibody, 100ul Erlenmeyer Flasks Take your experiments to theThis gene encodes a cyclin dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A p21. The encoded protein binds to and prevents the activation of cyclin E CDK2 or cyclin D CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from