LST8 Polyclonal Antibody, 100ul Contamination Detection & Removal Defects in this gene cause

Defects in this gene cause familial adenomatous polyposis (FAP)

Normally an integral-membrane protein

and also functions in lymphocyte costimulatory signaling

It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions

concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida

LST8 Polyclonal Antibody, 100ul Contamination Detection & Removal Defects in this gene causeUnessential component of the TORC1 complex and essential component of the TORC2 complex. TORC1 controls cell growth in response to environmental signals, and is inactivated by nutrient limitation and environmental stress. Within TORC1, LST8 interacts directly with FRAP1 and enhances its kinase activity. In nutrient poor conditions, stabilizes the FRAP1 RAPTOR interaction and favors RAPTOR mediated inhibition of FRAP1 activity. TORC2 controls polarity