Smad3 Polyclonal Antibody, 50ul[BT-AP08391] Bottles The string of histidine residues

The string of histidine residues binds to several types of immobilized metal ions

and then form homodimers

the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes

A similar murine protein interacts with TNFR-associated factor 1 (TRAF1)| TNFR-associated factor 2 (TRAF2)| and cylindromatosis

The encoded protein may anchor this complex to the nuclear envelope

Smad3 Polyclonal Antibody, 50ul[BT-AP08391] Bottles The string of histidine residuesThe protein encoded by SMAD3 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor beta and is thought to play a role in the regulation of