FXL12 Rabbit Polyclonal Antibody, 50ul Enzyme-Linked Immunosorbent Assay (ELISA) and a corresponding pseudogene has

and a corresponding pseudogene has been found on chromosome 22

Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele

Deletions and mutations in this gene were found in patients with mental retardation

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling| both in mature T-cells and during their development

Among its related pathways are Gene Expression and Cell Cycle

FXL12 Rabbit Polyclonal Antibody, 50ul Enzyme-Linked Immunosorbent Assay (ELISA) and a corresponding pseudogene hasMembers of the F box protein family such as FBXL12 are characterized by an approximately 40 amino acid F box motif. SCF complexes formed by SKP1 (MIM 601434) cullin (see CUL1; MIM 603134) and F box proteins act as protein ubiquitin ligases. F box proteins interact with SKP1 through the F box and they interact with ubiquitination targets through other protein interaction domains (Jin et al. 2004