DB134 Rabbit Polyclonal Antibody, 20ul Digital Burette Component of the probable SCF(FBXO7)

Component of the probable SCF(FBXO7) complex containing FBXO7

The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis| for instance| induced by G-protein-coupled-receptor signaling

Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors

The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction

Mutations at this locus have been associated with familial expansile osteolysis

DB134 Rabbit Polyclonal Antibody, 20ul Digital Burette Component of the probable SCF(FBXO7)Defensins are cysteine rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome with this gene mapping to a cluster at 8p23.