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ErbB-3 Polyclonal Antibody, 100ul[BT-AP03043] Lysosome This gene is located in

SKU: 84113758807

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ErbB-3 Polyclonal Antibody, 100ul[BT-AP03043] Lysosome This gene is located inERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation

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Description

This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias

including regulation of cell fate and patterning during embryogenesis

This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis

suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells

HLA-DMB belongs to the HLA class II beta chain paralogues

ErbB-3 Polyclonal Antibody, 100ul[BT-AP03043] Lysosome This gene is located inERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation

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