Mnk1(Phospho Thr255) Polyclonal Antibody, 20ul Proteases May be involved in transcriptional

May be involved in transcriptional regulation as a weak repressor when alone

The protein also functions in the regulation of the cell cycle in response to DNA damage

This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain

Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens

May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium

Mnk1(Phospho Thr255) Polyclonal Antibody, 20ul Proteases May be involved in transcriptionalThis gene encodes a Ser Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.