MARH7 Polyclonal Antibody, 20ul Antibody Humanization Three alternatively spliced transcript variants

Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described

Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation

The human 5-HT1F receptor is closely related to the 5-ht1E receptor and its gene has been localized to chromosome 3 (3q11)

Mutations and alternative splicing in TSG101 occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression

This copy of the gene is full-length and is in the telomeric duplicated region

MARH7 Polyclonal Antibody, 20ul Antibody Humanization Three alternatively spliced transcript variantsMARCH7 is a member of the MARCH family of membrane bound E3 ubiquitin ligases (EC 6. 3. 2. 19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004