Human Complement Component 5, C5 ELISA Kit , 96T DNA Oligo Synthesis The phosphodiesterase 10A encoded by

The phosphodiesterase 10A encoded by PDE10A belongs to the cyclic nucleotide phosphodiesterase family

Mutations in this gene are associated with cerebellar ataxia

Belongs to the LARP family

genomic imprinting

Defects in this gene cause Niemann-Pick type C disease| a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments

Human Complement Component 5, C5 ELISA Kit , 96T DNA Oligo Synthesis The phosphodiesterase 10A encoded byActivation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5 C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including