CD152 Polyclonal Antibody, 50ul Drug Development and Evaluation Mutations in this gene result

Mutations in this gene result in autosomal recessive spastic paraplegia

which interacts with histone deacetylase

They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates

This protein may also play a neuroprotective role during ischemic brain injury

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease

CD152 Polyclonal Antibody, 50ul Drug Development and Evaluation Mutations in this gene resultThis gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in