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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Yoon M.S

Ibuprofen significantly inhibited IgG production only in wild-type splenocytes (by ~ 70%) but did not inhibit IgG production in Cox-2 knock-out mice (Figure 3B

RNA was isolated using RNeasy Micro Kit (Qiagen, Venlo, Netherlands) according to the manufacturers instructions with minor modifications to the protocol

In particular, the interaction of ROS with NO, which is the best characterized (and likely most important) mediator of endothelial function, is felt to have an important role in determining the causal relationship between oxidative stress and hypertension