Human Interleukin-10 Receptor Subunit Alpha, IL10RA ELISA Kit, 96T Filtration This protein functions as a

This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis

The encoded protein serves as a ribosome release factor for this ribosome

Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype

These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents

At least eight components of the exocyst complex| including this protein| are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery

Human Interleukin-10 Receptor Subunit Alpha, IL10RA ELISA Kit, 96T Filtration This protein functions as aCell surface receptor for the cytokine IL10 that participates in IL10 mediated anti inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed: 16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively