MK Polyclonal Antibody, 100ul[BT-AP05435] Microplate Mixer Mutations in ITCH are a

Mutations in ITCH are a cause of syndromic multisystem autoimmune disease

intracellular acidification

This gene is a member of the Tre-2/BUB2/CDC16 domain family

The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1

whose members are related to the transforming genes of mammalian sarcoma retroviruses

MK Polyclonal Antibody, 100ul[BT-AP05435] Microplate Mixer Mutations in ITCH are aMDK encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. Midkine promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. MDK has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed.