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AChR Alpha5 Polyclonal Antibody, 50ul Plasmid Preparation Potassium ion channels are essential

SKU: 87743851209

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AChR Alpha5 Polyclonal Antibody, 50ul Plasmid Preparation Potassium ion channels are essentialCholinergic receptor nicotinic alpha 5 subunit encoded by CHRNA5 is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).

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Description

Potassium ion channels are essential to many cellular functions and show a high degree of diversity

A polymorphism in the terminal exon of this mRNA results in two protein isoforms

Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones

Mutations in this gene are associated with ataxia telangiectasia| an autosomal recessive disorder

Specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR)

AChR Alpha5 Polyclonal Antibody, 50ul Plasmid Preparation Potassium ion channels are essentialCholinergic receptor nicotinic alpha 5 subunit encoded by CHRNA5 is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).

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