LAT Polyclonal Antibody, 20ul[BT-AP04958] Lentiviral Packaging The 700-kD eukaryotic translation initiation

The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits

298 amino acid protein that contains three WD repeats

AIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein

Increased expression of CCDC88A and phosphorylation of the encoded protein may play a role in cancer metastasis

Three transcript variants encoding the same protein have been found for HCCS

LAT Polyclonal Antibody, 20ul[BT-AP04958] Lentiviral Packaging The 700-kD eukaryotic translation initiationThe protein encoded by LAT (linker for activation of T cells) is phosphorylated by ZAP 70 Syk protein tyrosine kinases following activation of the T cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling