PA21B Polyclonal Antibody, 50ul Inoculating Loops/Needles Three alternatively spliced transcript variants

Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene

two glycosylation sites

Phosphorylated during mitosis

colon and lung

The tyrosine kinase non receptor 2 may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc43Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway

PA21B Polyclonal Antibody, 50ul Inoculating Loops/Needles Three alternatively spliced transcript variantsThis gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium dependent enzyme catalyzes the hydrolysis of the sn 2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs)