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Insulin Polyclonal Antibody, 20ul[BT-AP10405] sgRNA Library Construction NECTIN2 encodes a single-pass type

SKU: 8948103063

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Insulin Polyclonal Antibody, 20ul[BT-AP10405] sgRNA Library Construction NECTIN2 encodes a single-pass typeAfter removal of the precursor signal peptide, proinsulin is post translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read through gene, INS IGF2, which overlaps with this gene at

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Description

NECTIN2 encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain

These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions

Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases

Does not affect the proliferation of cancer cells in vitro

This protein is thus a potential drug target for the treatment of muscle atrophy

Insulin Polyclonal Antibody, 20ul[BT-AP10405] sgRNA Library Construction NECTIN2 encodes a single-pass typeAfter removal of the precursor signal peptide, proinsulin is post translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read through gene, INS IGF2, which overlaps with this gene at

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