TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation namely the Shaw subfamily

namely the Shaw subfamily

Mutations in this gene cause Hermansky-Pudlak syndrome 8

Imprinting defects at chromosome 11p13 may contribute to tumorigenesis

The receptor functions as a neurotransmitter-gated ion channel

this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas

TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation namely the Shaw subfamilyCatalytic activity: ATP dependent breakage passage and rejoining of double stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils whereas prokaryotic enzymes relax only