PDHK1(Phospho Tyr243) Rabbit Polyclonal Antibody, 100ul[BT-AP11861] Cryogenic Vials The mitogen-activated protein kinase 8

The mitogen-activated protein kinase 8 interacting protein 2 encoded by MAPK8IP2 is closely related to MAPK8IP1/IB1/JIP-1

Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activition or by arresting cell growth in G1 phase in a p53-dependent manner

Core component of nucleosome

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mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia

PDHK1(Phospho Tyr243) Rabbit Polyclonal Antibody, 100ul[BT-AP11861] Cryogenic Vials The mitogen-activated protein kinase 8Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced