p38 MAPK Polyclonal Antibody, 20ul Recombinant Protein Allelic variations in this gene

Allelic variations in this gene have been associated| but not causally linked| with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS)

The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase

It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains

This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway

This gene is the second identified human homolog of the Drosophila fat gene

p38 MAPK Polyclonal Antibody, 20ul Recombinant Protein Allelic variations in this geneThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its