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doi:10.3389/fimmu.2021.785717

For instance, mild hypomethylation of bone-marrow MSCs amplifies their secretome and outperforms nave cells in cisplatin models, while coupling the same cells with neonatal ovarian aggregates yields an artificial ovary capable of folliculogenesis without uncontrolled proliferation

Voisin B

This perspective of loss-of-essential-PS-function in FAD differs from the amyloid cascade hypothesis, which postulates that the primary effect of PS mutations in FAD is through a toxic gain-of-function, by favoring the over-production of purportedly neurotoxic A42 species [93]