NFkB p65 Monoclonal Antibody(5G6), 100ul sgRNA Library Construction Mutations in HSD11B1 and H6PD

Mutations in HSD11B1 and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency

Interacts with HEXIM1 and MAP1S

It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus

Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor

Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection

NFkB p65 Monoclonal Antibody(5G6), 100ul sgRNA Library Construction Mutations in HSD11B1 and H6PDNF kappa B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF kappa B moves to the nucleus and activates transcription of specific genes. NF kappa B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF kappa B is NFKB1 complexed with the product of this gene, RELA. Four