Bag-4 Polyclonal Antibody, 100ul Cell Culture Flasks Members of the subfamily share

Members of the subfamily share similarity in sequence and splice sites

Belongs to the nuclear transition protein 2 family

Additional isoforms have been described for this gene but they have not yet been experimentally verified

Overexpression of this gene is seen in several cancers

thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed: 21602804)

Bag-4 Polyclonal Antibody, 100ul Cell Culture Flasks Members of the subfamily shareThe protein encoded by BAG4 is a member of the BAG1 related protein family. BAG1 is an anti apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL 2, Raf protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C terminus, which could bind and inhibit the chaperone activity