PBF Polyclonal Antibody, 50ul Drug Development and Evaluation This gene encodes a member

This gene encodes a member of the SH2B adaptor family of proteins

which are involved in a range of signaling activities by growth factor and cytokine receptors

enzyme regulation:Activated by phosphorylation on Thr-215 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39

This gene is expressed mainly in testis with weak expression in the brain

and polymorphisms that alter expression of ERCC1 may play a role in carcinogenesis

PBF Polyclonal Antibody, 50ul Drug Development and Evaluation This gene encodes a memberPTTG1IP (pituitary tumor transforming 1 interacting protein) encodes a single pass type I integral membrane protein, which binds to pituitary tumor transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for PTTG1IP.