BCL7C Polyclonal Antibody, 100ul Electrophoresis & Labeling Represses ligand-dependent transcriptional activation function

Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed: 25661920)

This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer

There are a number of related genes present on chromosomes 20 and 22| and putative pseudogenes for this gene on chromosomes 2| 13| and 22

it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream

BCL7C Polyclonal Antibody, 100ul Electrophoresis & Labeling Represses ligand-dependent transcriptional activation functionThis gene is identified by the similarity of its product to the N terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.