UHRF1 Monoclonal Antibody, 100ul Custom Peptide Synthesis Both N- and C-terminal domains

Both N- and C-terminal domains are required for transcriptional activation

A snoRNA gene (SNORD61) is found in one of its introns

where its expression increases in response to a downregulation of microRNAs

This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination

The protein encoded by STAT6 (signal transducer and activator of transcription 6) is a member of the STAT family of transcription factors

UHRF1 Monoclonal Antibody, 100ul Custom Peptide Synthesis Both N- and C-terminal domainsThis gene encodes a member of a subfamily of RING finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1 S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53 dependent DNA damage