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MSH2 Polyclonal Antibody, 50ul Electrophoresis & Labeling Grp78 and following heat shock

SKU: 93427309597

4.3
SEK162.00 SEK200.00

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MSH2 Polyclonal Antibody, 50ul Electrophoresis & Labeling Grp78 and following heat shockMSH2 is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

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Description

Grp78 and following heat shock

Activated by phosphorylation on Thr-211 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39

the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor

NR2 (GRIN2A

Diameter×depth:17×52

MSH2 Polyclonal Antibody, 50ul Electrophoresis & Labeling Grp78 and following heat shockMSH2 is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

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