ALS2 Polyclonal Antibody, 50ul Variant Libraries it plays an important role

it plays an important role in transcriptional regulation

subunit:Interacts with SH3GL1/endophilin-2

which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus

A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls| and repeat numbers in excess of 40 have been described as pathological

and increased levels of the encoded protein are associated with atherosclerotic lesions

ALS2 Polyclonal Antibody, 50ul Variant Libraries it plays an important roleThe protein encoded by this gene contains an ATS1 RCC1 like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics.