Rb Monoclonal Antibody, 50ul Bacterial Expression E3 ubiquitin-protein ligase UHRF1binds to

E3 ubiquitin-protein ligase UHRF1binds to specific DNA sequences

This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins

The precise function of this protein is unknown

Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene

USP36 (ubiquitin specific peptidase 36) encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases

Rb Monoclonal Antibody, 50ul Bacterial Expression E3 ubiquitin-protein ligase UHRF1binds toThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.