Rac GAP1(Phospho Ser387) Polyclonal Antibody, 20ul DNA/RNA Isolation & Purification Overexpression of PTK6 in mammary

Overexpression of PTK6 in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype

and Cryptic (CFC) family

the level of this protein in plasma increases greatly during acute phase response to tissue injury

The transforming protein that results is implicated in various malignancies

One pseudogene is known to exist

Rac GAP1(Phospho Ser387) Polyclonal Antibody, 20ul DNA/RNA Isolation & Purification Overexpression of PTK6 in mammaryThis gene encodes a GTPase activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on