Stat5a Polyclonal Antibody, 50ul[BT-AP08639] Polyclonal Antibody Preparation The protein encoded by this

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho| a protein involved in neurogenesis during embryonic development

The three 5' exons reside in the pseudoautosomal region and the remaining exons within the X-specific end

Ectopic expression of CDKN2C was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function

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The TRIM motif includes three zinc-binding domains| a RING| a B-box type 1 and a B-box type 2| and a coiled-coil region

Stat5a Polyclonal Antibody, 50ul[BT-AP08639] Polyclonal Antibody Preparation The protein encoded by thisStat5 is activated in response to a wide variety of ligands including IL 2, GM CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation. This phosphorylation is mediated by Src upon erythropoietin stimulation. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL 3, which suggests its involvement in angiogenesis and cell motility.