Shc(Phospho-Tyr317) Rabbit Polyclonal Antibody, 50ul Antibody Development targeting specific proteins for ubiquitin-mediated

targeting specific proteins for ubiquitin-mediated proteolysis

SPZ1 (spermatogenic leucine zipper 1) encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway

Reduced expression of this protein has been implicated in cardiomyopathies

the mature protein downregulates fibrinolysis

Related pseudogenes exist on chromosomes 9 and 15

Shc(Phospho-Tyr317) Rabbit Polyclonal Antibody, 50ul Antibody Development targeting specific proteins for ubiquitin-mediatedThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms p52Shc and p46Shc link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation. Unlike