Nkx-2.8 Polyclonal Antibody, 20ul Cell Culture somatic and familial gastrointestinal stromal

somatic and familial gastrointestinal stromal tumors

The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE)

a FAD-binding motif

suggesting its role in diverse biochemical activities related to signal transduction

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli

Nkx-2.8 Polyclonal Antibody, 20ul Cell Culture somatic and familial gastrointestinal stromalThe protein encoded by this gene is a homeobox containing developmental regulator associated with liver development. The encoded protein binds to the alpha fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung